Prairie du Chien is a city in and the county seat of Crawford County, Wisconsin, United States. The population was 5,911 at the 2010 census. Its ZIP Code is 53821.Often referred to as Wisconsin's second oldest city, Prairie du Chien was established as a European settlement by French voyageurs in the late seventeenth century. The city is located near the confluence of the Wisconsin and Mississippi rivers, a strategic point along the Fox-Wisconsin Waterway... Show more

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